Sensitive

Dupuytren's disease

LPP · rs56098053

Where this position leads

Condition: Dupuytren's Disease

rs56098053 Condition: Dupuytren's Disease Dupuytren's Disease Condition rs56098053 rs56098053 LPP

What the study found

Who was studied 11,320 European ancestry cases, 47,023 European ancestry controls; replicated in 3,248 European ancestry cases, 197,724 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.106 lower (95% confidence interval 0.076-0.137); p = 1 × 10−11.

Where it sits Chromosome 3, band 3q28 — in an intron of LPP.

What each result means

A/A Two copies of the version the research linked to Dupuytren's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Dupuytren's disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Dupuytren's disease. This is the starting point the study compared everyone against.
Source

Questions about rs56098053

What is rs56098053?

rs56098053 is a single position in the genome, in or near the LPP gene. Published research associates it with dupuytren's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs56098053 linked to?

On MyGeneLog this position is linked to Dupuytren's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs56098053 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs56098053 come from?

GWAS Catalog, Nature communications 2024, PMID:38172110. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Dupuytren's disease (rs56098053). MyGeneLog™. https://www.mygenelog.com/variants/rs56098053

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