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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 43,148 European ancestry individuals; replicated in 1,179 Central or South Asian individuals, 1,161 African ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.273 lower (95% confidence interval 0.21-0.34); p = 1 × 10−17.
How common The A allele had a frequency of about 40% in the people studied.
Where it sits Chromosome 7, band 7q36.3 — between genes, 11.3 kb from SHH.
What each result means
A/ATwo copies of the version the research linked to Retinal thickness (pixel 47_199). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Retinal thickness (pixel 47_199). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Retinal thickness (pixel 47_199). This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 39904976 · open access
Questions about rs56021560
What is rs56021560?
rs56021560 is a single position in the genome, in or near the near SHH gene. Published research associates it with retinal thickness (pixel 47_199). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs56021560 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs56021560 come from?
GWAS Catalog, Nature communications 2025, PMID:39904976. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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