Standard

Chronotype

near ASB1 · rs55986470

Where this position leads

What the study found

Who was studied 101,185 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.037 higher (95% confidence interval 0.025-0.049); p = 2 × 10⁻⁹.

How common The G allele had a frequency of about 15% in the people studied.

Where it sits Chromosome 2, band 2q37.3 — in a non-coding transcript of LOC100419686.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Chronotype — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronotype.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronotype compared to the general population.

Source

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

Hammerschlag AR, Stringer S, de Leeuw CA, Sniekers S, Taskesen E, Watanabe K, Blanken TF, Dekker K, Te Lindert BHW, Wassing R, Jonsdottir I, Thorleifsson G

and 10 more — show all

Stefansson H, Gislason T, Berger K, Schormair B, Wellmann J, Winkelmann J, Stefansson K, Oexle K, Van Someren EJW, Posthuma D

Nature genetics · 2017 · PMID 28604731 · open access

Questions about rs55986470

What is rs55986470?

rs55986470 is a single position in the genome, in or near the near ASB1 gene. Published research associates it with chronotype. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs55986470 linked to?

On MyGeneLog this position is linked to Sleep and Circadian Rhythm. The research behind each link, and its sources, are set out on that condition page.

Does having rs55986470 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55986470 come from?

GWAS Catalog, Nat Genet 2017, PMID:28604731. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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