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Total cholesterol levels

MITF · rs55921103

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0141 higher (95% confidence interval 0.011-0.017); p = 1 × 10−16.

How common The T allele had a frequency of about 64% in the people studied.

Where it sits Chromosome 3, band 3p13 — in an intron of MITF.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Total cholesterol levels — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total cholesterol levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total cholesterol levels compared to the general population.
Source

Questions about rs55921103

What is rs55921103?

rs55921103 is a single position in the genome, in or near the MITF gene. Published research associates it with total cholesterol levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs55921103 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55921103 come from?

GWAS Catalog, Nature 2021, PMID:34887591. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total cholesterol levels (rs55921103). MyGeneLog™. https://www.mygenelog.com/variants/rs55921103

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