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Cathepsin D levels

CTSD · rs55861089

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 21,758 European ancestry individuals; replicated in 9,173 individuals.

The effect Each copy of the A allele shifted the measure 0.437 higher; p = 7 × 10−224.

How common The A allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 11, band 11p15.5 — in an intron of CTSD.

What each result means

A/A Two copies of the version the research linked to Cathepsin D levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Cathepsin D levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to Cathepsin D levels. This is the starting point the study compared everyone against.
Source
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals
Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE
and 71 more — show all
Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A
Nature metabolism · 2020 · PMID 33067605

Questions about rs55861089

What is rs55861089?

rs55861089 is a single position in the genome, in or near the CTSD gene. Published research associates it with cathepsin d levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs55861089 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55861089 come from?

GWAS Catalog, Nature metabolism 2020, PMID:33067605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cathepsin D levels (rs55861089). MyGeneLog™. https://www.mygenelog.com/variants/rs55861089

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