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Cortical surface area

LINC02944 · rs558358405

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 35,657 White British ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 3 × 10⁻¹⁰.

How common The T allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 10, band 10q26.11 — in an intron of LINC02944.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Cortical surface area — no copies of the reported risk allele.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cortical surface area.

T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cortical surface area compared to the general population.

Source

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology

Shadrin AA, Kaufmann T, van der Meer D, Palmer CE, Makowski C, Loughnan R, Jernigan TL, Seibert TM, Hagler DJ, Smeland OB, Motazedi E, Chu Y

and 10 more — show all

Lin A, Cheng W, Hindley G, Thompson WK, Fan CC, Holland D, Westlye LT, Frei O, Andreassen OA, Dale AM

NeuroImage · 2021 · PMID 34560273

Questions about rs558358405

What is rs558358405?

rs558358405 is a single position in the genome, in or near the LINC02944 gene. Published research associates it with cortical surface area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs558358405 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs558358405 come from?

GWAS Catalog, NeuroImage 2021, PMID:34560273. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cortical surface area (rs558358405). MyGeneLog™. https://www.mygenelog.com/variants/rs558358405

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