Brain age gap derived from combined gray and white matter
near NPM1P46 · rs55775495
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 54,890 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.127 years higher (95% confidence interval 0.086-0.168); p = 1 × 10−9.
How common The T allele had a frequency of about 65% in the people studied.
Where it sits Chromosome 2, band 2q33.1 — between genes, 0.3 kb from NPM1P46.
What each result means
C/CNo copy of the version the research linked to Brain age gap derived from combined gray and white matter. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Brain age gap derived from combined gray and white matter. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Brain age gap derived from combined gray and white matter. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs55775495 is a single position in the genome, in or near the near NPM1P46 gene. Published research associates it with brain age gap derived from combined gray and white matter. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs55775495 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs55775495 come from?
GWAS Catalog, Nature aging 2025, PMID:41044200. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Brain age gap derived from combined gray and white matter (rs55775495). MyGeneLog™. https://www.mygenelog.com/variants/rs55775495