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Cerebellar grey matter morphology (MOSTest)

EFNA5 · rs55754532

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10⁻¹², with 2 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 27,302 European ancestry individuals; replicated in 11,264 European ancestry individuals.

The effect The reported allele is G; the catalogue records no effect size ; p = 8 × 10⁻¹¹.

Where it sits Chromosome 5, band 5q21.3 — in an intron of EFNA5.

What each result means

A/A No copy of the version the research linked to Cerebellar grey matter morphology (MOSTest). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Cerebellar grey matter morphology (MOSTest). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Cerebellar grey matter morphology (MOSTest). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology

Moberget T, van der Meer D, Bahrami S, Roelfs D, Frei O, Kaufmann T, Fernandez-Cabello S, Kim M, Wolfers T, Diedrichsen J, Smeland OB, Shadrin A

and 3 more — show all

Dale A, Andreassen OA, Westlye LT

Communications biology · 2026 · PMID 41703085 · open access

Questions about rs55754532

What is rs55754532?

rs55754532 is a single position in the genome, in or near the EFNA5 gene. Published research associates it with cerebellar grey matter morphology (mostest). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs55754532 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55754532 come from?

GWAS Catalog, Communications biology 2026, PMID:41703085. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cerebellar grey matter morphology (MOSTest) (rs55754532). MyGeneLog™. https://www.mygenelog.com/variants/rs55754532

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