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General risk tolerance (MTAG)

NFASC · rs55678495

Where this position leads

What the study found

Who was studied 975,353 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0126 higher (95% confidence interval 0.0095-0.0157); p = 6 × 10⁻¹⁵.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — a synonymous change in NFASC.

What ClinVar records

Classification Benign for NFASC-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-12-03. ClinVar record 3060648 NM_001005388.3(NFASC):c.3309G>A (p.Ala1103=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to General risk tolerance (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to General risk tolerance (MTAG). That is a smaller link than two copies.

G/G No copy of the version the research linked to General risk tolerance (MTAG). This is the starting point the study compared everyone against.

Source

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A

and 80 more — show all

Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP

23and Me Research Team · eQTLgen Consortium · International Cannabis Consortium · Social Science Genetic Association Consortium

Nature genetics · 2019 · PMID 30643258

Questions about rs55678495

What is rs55678495?

rs55678495 is a single position in the genome, in or near the NFASC gene. Published research associates it with general risk tolerance (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs55678495 linked to?

On MyGeneLog this position is linked to Adventurousness. The research behind each link, and its sources, are set out on that condition page.

Does having rs55678495 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs55678495 come from?

GWAS Catalog, Nature genetics 2019, PMID:30643258. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

General risk tolerance (MTAG) (rs55678495). MyGeneLog™. https://www.mygenelog.com/variants/rs55678495

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