Standard

Glaucoma

ELP4 · rs555091

Where this position leads

Condition: Glaucoma

rs555091 Condition: Glaucoma Glaucoma Condition rs555091 rs555091 ELP4

What the study found

Who was studied 658 African American prevalent cases, 1,062 African American incident cases, 6,067 African American controls, 153 Hispanic prevalent cases, 336 Hispanic incident cases, 2,685 Hispanic controls.

The effect Each copy of the C allele carried 1.92 times the odds of Glaucoma (95% confidence interval 1.53-2.41); p = 2 × 10−8.

How common The C allele had a frequency of about 2% in the people studied.

Where it sits Chromosome 11, band 11p13 — in an intron of ELP4.

What each result means

C/C Two copies of the version the research linked to Glaucoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Glaucoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Glaucoma. This is the starting point the study compared everyone against.
Source

Questions about rs555091

What is rs555091?

rs555091 is a single position in the genome, in or near the ELP4 gene. Published research associates it with glaucoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs555091 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs555091 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs555091 come from?

GWAS Catalog, Hum Mol Genet 2014, PMID:25027321. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glaucoma (rs555091). MyGeneLog™. https://www.mygenelog.com/variants/rs555091

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