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Takes medication for gout?

PNKP · rs552615101

Where this position leads

Condition: Gout

rs552615101 Condition: Gout Gout Condition rs552615101 rs552615101 PNKP

What the study found

Who was studied 4,708 African American or Afro-Caribbean cases, 50,797 African American or Afro-Caribbean controls, 1,396 Hispanic or Latin American cases, 27,918 Hispanic or Latin American controls, 573 East Asian ancestry cases, 2,974 East Asian ancestry controls, 20,817 European ancestry cases, 294,851 European ancestry controls.

The effect Each copy of the C allele shifted the measure 1.92 lower (95% confidence interval 1.87-1.97); p = 7 × 10−20.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 19, band 19q13.33 — in an intron of PNKP.

What each result means

C/C Two copies of the version the research linked to Takes medication for gout?. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Takes medication for gout?. That is a smaller link than two copies.
T/T No copy of the version the research linked to Takes medication for gout?. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs552615101

What is rs552615101?

rs552615101 is a single position in the genome, in or near the PNKP gene. Published research associates it with takes medication for gout?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs552615101 linked to?

On MyGeneLog this position is linked to Gout. The research behind each link, and its sources, are set out on that condition page.

Does having rs552615101 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs552615101 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for gout? (rs552615101). MyGeneLog™. https://www.mygenelog.com/variants/rs552615101

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