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Cholesterol levels in large LDL

DMRT1 · rs550637604

What the study found

Who was studied 115,082 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.333 lower (95% confidence interval 0.22-0.45); p = 2 × 10−8.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 9, band 9p24.3 — in an intron of DMRT1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Cholesterol levels in large LDL — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Cholesterol levels in large LDL.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Cholesterol levels in large LDL compared to the general population.
Source

Questions about rs550637604

What is rs550637604?

rs550637604 is a single position in the genome, in or near the DMRT1 gene. Published research associates it with cholesterol levels in large ldl. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs550637604 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs550637604 come from?

GWAS Catalog, PLoS biology 2022, PMID:35213538. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cholesterol levels in large LDL (rs550637604). MyGeneLog™. https://www.mygenelog.com/variants/rs550637604

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