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Total testosterone levels

WDR81 · rs550628400

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 194,453 European ancestry men.

The effect Each copy of the G allele shifted the measure 0.134 higher (95% confidence interval 0.095-0.174); p = 9 × 10⁻¹¹.

How common The G allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 17, band 17p13.3 — in an intron of WDR81-AS1.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Total testosterone levels — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Total testosterone levels.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Total testosterone levels compared to the general population.

Source

Using human genetics to understand the disease impacts of testosterone in men and women

Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L, Martin S, Busch AS, Erzurumluoglu AM, Hollis B

and 10 more — show all

O'Mara TA, McCarthy MI, Langenberg C, Easton DF, Wareham NJ, Burgess S, Murray A, Ong KK, Frayling TM, Perry JRB

Endometrial Cancer Association Consortium

Nature medicine · 2020 · PMID 32042192 · open access

Questions about rs550628400

What is rs550628400?

rs550628400 is a single position in the genome, in or near the WDR81 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs550628400 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs550628400 come from?

GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Total testosterone levels (rs550628400). MyGeneLog™. https://www.mygenelog.com/variants/rs550628400

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