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Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia

FAM184B · rs550571596

What the study found

Who was studied 361 European ancestry cases, 656,254 European ancestry controls.

The effect Each copy of the A allele carried 11.88 times the odds of Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia (95% confidence interval 5.09-27.77); p = 1 × 10−8.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 4, band 4p15.32 — in an intron of FAM184B.

What each result means

A/A Two copies of the version the research linked to Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/T One copy of the version the research linked to Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia. That is a smaller link than two copies.
T/T No copy of the version the research linked to Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia. This is the starting point the study compared everyone against.
Source

Questions about rs550571596

What is rs550571596?

rs550571596 is a single position in the genome, in or near the FAM184B gene. Published research associates it with lymphoplasmacytic lymphoma and waldenstrom macroglobulinemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs550571596 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs550571596 come from?

GWAS Catalog, Blood cancer journal 2025, PMID:40883272. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lymphoplasmacytic lymphoma and Waldenstrom macroglobulinemia (rs550571596). MyGeneLog™. https://www.mygenelog.com/variants/rs550571596

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