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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 408,111 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 4.74 higher (95% confidence interval 3.27-6.21); p = 3 × 10−10.
Where it sits Chromosome 5, band 5q21.3 — in an intron of EFNA5.
What each result means
C/CTwo copies of the version the research linked to Hematocrit variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Hematocrit variance. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Hematocrit variance. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40335489 · open access
Questions about rs550563462
What is rs550563462?
rs550563462 is a single position in the genome, in or near the EFNA5 gene. Published research associates it with hematocrit variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs550563462 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs550563462 come from?
GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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