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Standard

Height

DYM · rs549201

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−300, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 4,080,687 European ancestry individuals; replicated in 49,160 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0318 higher (95% confidence interval 0.03-0.033); p = 1 × 10−300.

How common The T allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 18, band 18q21.1 — in an intron of DYM.

How common each version is

CT
Korean KRGDB
C 61.7% · T 38.3%
Korean Korea4K
C 61.9% · T 38.1%
Japanese ToMMo
C 64.1% · T 35.9%
Vietnamese
C 55.2% · T 44.8%
World gnomAD
C 45.9% · T 54.1%
World 1000 Genomes
C 53.3% · T 46.7%
World TOPMed
C 46.9% · T 53.1%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Height. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

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Height (rs549201). MyGeneLog™. https://www.mygenelog.com/variants/rs549201

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