Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
3 / 4
Its strongest genetic-study result is p = 10−96, with 40 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 99,432 Admixed African or African ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.176 higher (95% confidence interval 0.16-0.19); p = 4 × 10−97.
How common The C allele had a frequency of about 11% in the people studied.
Where it sits Chromosome 16, band 16q22.2 — in the 5′ untranslated region of HP.
What ClinVar records
ClassificationAffects for Anhaptoglobinemia; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2003-11-01.
ClinVar record 15901NM_005143.5(HP):c.-91A>C
Change history
MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-11-01 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ANo copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Total cholesterol levels (rs5471). MyGeneLog™. https://www.mygenelog.com/variants/rs5471