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Standard

Total cholesterol levels

HP · rs5471

Strength of the evidence

3 / 4

Its strongest genetic-study result is p = 10−96, with 40 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 99,432 Admixed African or African ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.176 higher (95% confidence interval 0.16-0.19); p = 4 × 10−97.

How common The C allele had a frequency of about 11% in the people studied.

Where it sits Chromosome 16, band 16q22.2 — in the 5′ untranslated region of HP.

What ClinVar records

Classification Affects for Anhaptoglobinemia; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2003-11-01. ClinVar record 15901 NM_005143.5(HP):c.-91A>C

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-01 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
DNA databases also record a third, rare version at this position, carried on fewer than one in a hundred copies of the DNA. The three results above cover the two common versions only.
Source

Quoting this page

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Total cholesterol levels (rs5471). MyGeneLog™. https://www.mygenelog.com/variants/rs5471

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