0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 257,365 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,186,763 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the T allele shifted the measure 0.224 higher (95% confidence interval 0.16-0.29); p = 2 × 10−11.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 19, band 19q13.2 — in the 3′ untranslated region of SPTBN4.
What each result means
C/CNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs545497890
What is rs545497890?
rs545497890 is a single position in the genome, in or near the SPTBN4 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs545497890 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs545497890 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs545497890 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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