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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.372 lower (95% confidence interval 0.26-0.48); p = 3 × 10−12.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 2, band 2p22.2 — in an intron of FEZ2.
What each result means
C/CNo copy of the version the research linked to VIT protein levels. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to VIT protein levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to VIT protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs545095845
What is rs545095845?
rs545095845 is a single position in the genome, in or near the FEZ2 gene. Published research associates it with vit protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs545095845 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs545095845 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs545095845 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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VIT protein levels (rs545095845). MyGeneLog™. https://www.mygenelog.com/variants/rs545095845