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TTF2 protein levels

near PTGFRN · rs545013863

Where this position leads

Condition: Celiac Disease

rs545013863 Condition: Celiac Disease Celiac Disease Condition rs545013863 rs545013863 near PTGFRN

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.572 higher (95% confidence interval 0.41-0.74); p = 1 × 10−12.

How common The A allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 1, band 1p13.1 — between genes, 36.3 kb from PTGFRN.

What each result means

A/A Two copies of the version the research linked to TTF2 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to TTF2 protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to TTF2 protein levels. This is the starting point the study compared everyone against.
Source

Questions about rs545013863

What is rs545013863?

rs545013863 is a single position in the genome, in or near the near PTGFRN gene. Published research associates it with ttf2 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs545013863 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs545013863 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs545013863 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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TTF2 protein levels (rs545013863). MyGeneLog™. https://www.mygenelog.com/variants/rs545013863

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