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Chronic obstructive asthma with exacerbation (PheCode 495.11)

DNHD1 · rs543922638

Where this position leads

Condition: Asthma

rs543922638 Condition: Asthma Asthma Condition rs543922638 rs543922638 DNHD1

What the study found

Who was studied 396 African American or Afro-Caribbean cases, 120,899 African American or Afro-Caribbean controls, 1,086 European ancestry cases, 448,036 European ancestry controls.

The effect Each copy of the T allele shifted the measure 2.19 lower (95% confidence interval 2.13-2.24); p = 1 × 10−11.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 11, band 11p15.4 — in an intron of DNHD1.

What each result means

C/C No copy of the version the research linked to Chronic obstructive asthma with exacerbation (PheCode 495.11). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Chronic obstructive asthma with exacerbation (PheCode 495.11). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Chronic obstructive asthma with exacerbation (PheCode 495.11). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs543922638

What is rs543922638?

rs543922638 is a single position in the genome, in or near the DNHD1 gene. Published research associates it with chronic obstructive asthma with exacerbation (phecode 495.11). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs543922638 linked to?

On MyGeneLog this position is linked to Asthma. The research behind each link, and its sources, are set out on that condition page.

Does having rs543922638 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs543922638 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Chronic obstructive asthma with exacerbation (PheCode 495.11) (rs543922638). MyGeneLog™. https://www.mygenelog.com/variants/rs543922638

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