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Mean corpuscular hemoglobin concentration variance

HBE1 · rs542968504

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 407,849 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.604 higher (95% confidence interval 0.42-0.79); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 11, band 11p15.4 — in an intron of HBE1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mean corpuscular hemoglobin concentration variance compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mean corpuscular hemoglobin concentration variance.

G/G Published research associates this genotype with typical/baseline likelihood of Mean corpuscular hemoglobin concentration variance — no copies of the reported risk allele.

Source

Genome-wide analyses of variance in blood cell phenotypes provide new insights into complex trait biology and prediction

Xiang R, Ben-Eghan C, Liu Y, Roberts D, Ritchie S, Lambert SA, Xu Y, Takeuchi F, Inouye M

Nature communications · 2025 · PMID 40335489 · open access

Questions about rs542968504

What is rs542968504?

rs542968504 is a single position in the genome, in or near the HBE1 gene. Published research associates it with mean corpuscular hemoglobin concentration variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs542968504 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs542968504 come from?

GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Mean corpuscular hemoglobin concentration variance (rs542968504). MyGeneLog™. https://www.mygenelog.com/variants/rs542968504

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