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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 83,677 British ancestry cases, 244,662 British ancestry controls; replicated in 2,764 South Asian ancestry cases, 3,139 African Caribbean ancestry cases, 16,169 European ancestry cases, 3,866 mixed ancestry cases, 4,267 South Asian ancestry controls, 4,341 African Caribbean ancestry controls, 31,814 European ancestry controls, 5,988 mixed ancestry controls.
The effect
Each copy of the A allele shifted the measure 0.053 higher (95% confidence interval 0.043-0.063); p = 4 × 10−23.
How common The A allele had a frequency of about 39% in the people studied.
Where it sits Chromosome 3, band 3p12.1 — in an intron of CADM2.
What each result means
A/ATwo copies of the version the research linked to Self-reported risk-taking behaviour. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/TOne copy of the version the research linked to Self-reported risk-taking behaviour. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Self-reported risk-taking behaviour. This is the starting point the study compared everyone against.
Translational psychiatry · 2018 · PMID 30181555 · open access
Questions about rs542809491
What is rs542809491?
rs542809491 is a single position in the genome, in or near the CADM2 gene. Published research associates it with self-reported risk-taking behaviour. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs542809491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs542809491 come from?
GWAS Catalog, Translational psychiatry 2018, PMID:30181555. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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