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Who was studied 257,365 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern cases, 2,186,763 African ancestry, admixed American, East Asian ancestry, European ancestry, South Asian ancestry, Greater Middle Eastern controls.
The effect
Each copy of the C allele shifted the measure 0.205 higher (95% confidence interval 0.15-0.26); p = 3 × 10−15.
How common The C allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 2, band 2q11.2 — between genes, 6.7 kb from NEURL3.
What each result means
C/CTwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs542166863
What is rs542166863?
rs542166863 is a single position in the genome, in or near the near NEURL3 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs542166863 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs542166863 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs542166863 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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