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Aurora kinase B levels

CFB · rs541862

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.271 lower (95% confidence interval 0.23-0.32); p = 5 × 10⁻³³.

How common The T allele had a frequency of about 90% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of CFB.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-06-18. ClinVar record 1283922 NM_001710.6(CFB):c.1169-69T>C

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Aurora kinase B levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Aurora kinase B levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Aurora kinase B levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Mapping the proteo-genomic convergence of human diseases

Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J, Stewart ID, Kerrison ND, Luan J, Raffler J

and 9 more — show all

Arnold M, Arlt W, O'Rahilly S, Kastenmüller G, Gamazon ER, Hingorani AD, Scott RA, Wareham NJ, Langenberg C

Science (New York, N.Y.) · 2021 · PMID 34648354

Questions about rs541862

What is rs541862?

rs541862 is a single position in the genome, in or near the CFB gene. Published research associates it with aurora kinase b levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs541862 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs541862 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Aurora kinase B levels (rs541862). MyGeneLog™. https://www.mygenelog.com/variants/rs541862

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