CEL · rs541856133
Where this position leads
Condition: Type 1 Diabetes
What the study found
Who was studied 18,942 European ancestry cases, 501,638 European ancestry controls.
The effect Each copy of the T allele shifted the measure 1.1 higher (95% confidence interval 0.85-1.36); p = 4 × 10−17.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 9, band 9q34.13 — in a regulatory region of LOC124902325.
What ClinVar records
Classification
Likely benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2023-02-01.
ClinVar record 2659663 NC_000009.12:g.133060938C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs541856133 is a single position in the genome, in or near the CEL gene. Published research associates it with type 1 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Type 1 Diabetes. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature 2021, PMID:34012112. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 1 diabetes (rs541856133). MyGeneLog™. https://www.mygenelog.com/variants/rs541856133