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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−11, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 418 African American or Afro-Caribbean cases, 120,624 African American or Afro-Caribbean controls, 1,743 European ancestry cases, 445,957 European ancestry controls, 209 Hispanic or Latin American cases, 59,243 Hispanic or Latin American controls.
The effect
Each copy of the G allele shifted the measure 2.57 lower (95% confidence interval 2.53-2.61); p = 1 × 10−11.
How common The G allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 7, band 7q11.22 — between genes, 13.7 kb from CALN1.
What each result means
A/ANo copy of the version the research linked to Peritoneal adhesions (postoperative) (postinfection) (PheCode 568.1). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Peritoneal adhesions (postoperative) (postinfection) (PheCode 568.1). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Peritoneal adhesions (postoperative) (postinfection) (PheCode 568.1). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs541506469
What is rs541506469?
rs541506469 is a single position in the genome, in or near the near CALN1 gene. Published research associates it with peritoneal adhesions (postoperative) (postinfection) (phecode 568.1). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs541506469 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs541506469 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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