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Who was studied 9,863 European ancestry cases, 716,791 European ancestry controls, 12,796 Estonian, Russian or unknown ancestry cases, 186,199 Estonian, Russian or unknown ancestry controls.
The effect
Each copy of the C allele carried 1.83 times the odds of Psoriasis (95% confidence interval 1.49-2.26); p = 1 × 10−8.
How common The C allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 3, band 3p12.3 — in an intron of ROBO1.
What each result means
C/CTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
The Journal of investigative dermatology · 2024 · PMID 38763176
Questions about rs540696640
What is rs540696640?
rs540696640 is a single position in the genome, in or near the ROBO1 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs540696640 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs540696640 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs540696640 come from?
GWAS Catalog, The Journal of investigative dermatology 2024, PMID:38763176. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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