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Who was studied 16,595 European ancestry cases, 523,330 European ancestry controls.
The effect
Each copy of the G allele carried 2.48 times the odds of Uterine fibroids (95% confidence interval 1.88-3.26); p = 2 × 10−10.
How common The G allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 4, band 4p12 — between genes, 174.7 kb from RNU6-931P.
What each result means
C/CNo copy of the version the research linked to Uterine fibroids. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Uterine fibroids. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Uterine fibroids. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 30194396 · open access
Questions about rs540409605
What is rs540409605?
rs540409605 is a single position in the genome, in or near the GABRG1 gene. Published research associates it with uterine fibroids. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs540409605 linked to?
On MyGeneLog this position is linked to Uterine Fibroids. The research behind each link, and its sources, are set out on that condition page.
Does having rs540409605 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs540409605 come from?
GWAS Catalog, Nature communications 2018, PMID:30194396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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