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Platelet count

SIK3 · rs539858

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 38,000 South Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.06 lower (95% confidence interval 0.04-0.08); p = 2 × 10⁻¹⁰.

Where it sits Chromosome 11, band 11q23.3 — a synonymous change in SIK3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Platelet count compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Platelet count.

T/T Published research associates this genotype with typical/baseline likelihood of Platelet count — no copies of the reported risk allele.

Source

Genetic architecture of routinely acquired blood tests in a British South Asian cohort

Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K, Langenberg C, Dobson R, Finer S, Morton C

and 5 more — show all

Siddiqui MK, Martin HC, Pietzner M, Mathur R, van Heel DA

Genes & Health Research Team

Nature communications · 2024 · PMID 39414775 · open access

Questions about rs539858

What is rs539858?

rs539858 is a single position in the genome, in or near the SIK3 gene. Published research associates it with platelet count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs539858 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs539858 come from?

GWAS Catalog, Nature communications 2024, PMID:39414775. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Platelet count (rs539858). MyGeneLog™. https://www.mygenelog.com/variants/rs539858

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