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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,634 Sardinian (founder/genetic isolate) ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.823 higher (95% confidence interval 0.59-1.05); p = 4 × 10−12.
How common The G allele had a frequency of about 4% in the people studied.
Where it sits Chromosome 6, band 6p21.32 — between genes, 16.9 kb from HLA-DRB1.
What each result means
A/ANo copy of the version the research linked to HLA DR on CD33dim HLA DR+ CD11b+. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to HLA DR on CD33dim HLA DR+ CD11b+. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to HLA DR on CD33dim HLA DR+ CD11b+. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs539705259 is a single position in the genome, in or near the near HLA-DRB1 gene. Published research associates it with hla dr on cd33dim hla dr+ cd11b+. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs539705259 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs539705259 come from?
GWAS Catalog, Nature genetics 2020, PMID:32929287. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
HLA DR on CD33dim HLA DR+ CD11b+ (rs539705259). MyGeneLog™. https://www.mygenelog.com/variants/rs539705259