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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 8,809 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.602 higher (95% confidence interval 0.45-0.75); p = 1 × 10−14.
Where it sits Chromosome 16, band 16p12.1 — between genes, 2 kb from GAPDHP35.
What each result means
A/ANo copy of the version the research linked to P-cresol-glucuronide levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to P-cresol-glucuronide levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to P-cresol-glucuronide levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs539659446 is a single position in the genome, in or near the near GAPDHP35 gene. Published research associates it with p-cresol-glucuronide levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs539659446 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs539659446 come from?
GWAS Catalog, Metabolites 2022, PMID:35050183. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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