Alzheimer disease in high polygenic risk score (>65th percentile)
ALDH9A1 · rs539602997
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,180 European ancestry cases, 978 European ancestry controls.
The effect
Each copy of the A allele carried 0.02 times the odds of Alzheimer disease in high polygenic risk score (>65th percentile) (95% confidence interval 0.00661458886758494-0.0848513583196374); p = 9 × 10−9.
Where it sits Chromosome 1, band 1q24.1 — in an intron of ALDH9A1.
What each result means
A/ATwo copies of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Alzheimer disease in high polygenic risk score (>65th percentile). This is the starting point the study compared everyone against.
Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026 · PMID 42557982 · open access
Questions about rs539602997
What is rs539602997?
rs539602997 is a single position in the genome, in or near the ALDH9A1 gene. Published research associates it with alzheimer disease in high polygenic risk score (>65th percentile). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs539602997 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs539602997 come from?
GWAS Catalog, Alzheimer's & dementia : the journal of the Alzheimer's Association 2026, PMID:42557982. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Alzheimer disease in high polygenic risk score (>65th percentile) (rs539602997). MyGeneLog™. https://www.mygenelog.com/variants/rs539602997