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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 406,469 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 4.78 higher (95% confidence interval 3.3-6.25); p = 2 × 10−10.
Where it sits Chromosome 7, band 7p11.2 — in the 5′ untranslated region of NIPSNAP2.
What each result means
G/GNo copy of the version the research linked to Eosinophil count variance. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Eosinophil count variance. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Eosinophil count variance. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 40335489 · open access
Questions about rs538947258
What is rs538947258?
rs538947258 is a single position in the genome, in or near the NIPSNAP2 gene. Published research associates it with eosinophil count variance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs538947258 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs538947258 come from?
GWAS Catalog, Nature communications 2025, PMID:40335489. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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