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CTSH protein levels

near PSMA4 · rs538697229

Where this position leads

Condition: Celiac Disease

rs538697229 Condition: Celiac Disease Celiac Disease Condition rs538697229 rs538697229 near PSMA4

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 1.05 higher (95% confidence interval 0.88-1.23); p = 5 × 10−39.

How common The T allele had a frequency of about 0% in the people studied.

Where it sits Chromosome 15, band 15q25.1 — between genes, 0.6 kb from PSMA4.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of CTSH protein levels — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with CTSH protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of CTSH protein levels compared to the general population.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs538697229

What is rs538697229?

rs538697229 is a single position in the genome, in or near the near PSMA4 gene. Published research associates it with ctsh protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs538697229 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs538697229 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs538697229 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

CTSH protein levels (rs538697229). MyGeneLog™. https://www.mygenelog.com/variants/rs538697229

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