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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−18, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 448,010 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.18 lower (95% confidence interval 0.14-0.22); p = 6 × 10−19.
Where it sits Chromosome 7, band 7q31.31 — in an intron of CPED1.
What each result means
A/ANo copy of the version the research linked to Estimated bone mineral density. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Estimated bone mineral density. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Estimated bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42432248 · open access
Questions about rs538304675
What is rs538304675?
rs538304675 is a single position in the genome, in or near the CPED1 gene. Published research associates it with estimated bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs538304675 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs538304675 come from?
GWAS Catalog, Nature genetics 2026, PMID:42432248. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Estimated bone mineral density (rs538304675). MyGeneLog™. https://www.mygenelog.com/variants/rs538304675