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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 1.21 higher (95% confidence interval 1.07-1.34); p = 8 × 10−82.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 16, band 16p13.3 — in an intron of UBE2I.
What each result means
C/CNo copy of the version the research linked to TPSAB1 protein levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to TPSAB1 protein levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to TPSAB1 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs537821715
What is rs537821715?
rs537821715 is a single position in the genome, in or near the UBE2I gene. Published research associates it with tpsab1 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs537821715 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs537821715 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs537821715 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 165227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot5Amazon2Apple2China (ByteDance, Huawei, Baidu…)0Others7Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TPSAB1 protein levels (rs537821715). MyGeneLog™. https://www.mygenelog.com/variants/rs537821715