Gene Knowledge Graph
UTC
Standard

Acute laryngitis and tracheitis (PheCode 465.4)

near ECM1P2 · rs536304276

Where this position leads

Condition: Acute Laryngitis and Tracheitis

rs536304276 Condition: Acute Laryngitis and Tracheitis Acute Laryngitis and Tracheitis Condition rs536304276 rs536304276 near ECM1P2

What the study found

Who was studied 243 African American or Afro-Caribbean cases, 120,331 African American or Afro-Caribbean controls, 642 European ancestry cases, 446,916 European ancestry controls.

The effect Each copy of the T allele shifted the measure 3.53 lower (95% confidence interval 3.51-3.54); p = 8 × 10−14.

How common The T allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 4, band 4p15.33 — between genes, 114.6 kb from ECM1P2.

What each result means

C/C No copy of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Acute laryngitis and tracheitis (PheCode 465.4). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs536304276

What is rs536304276?

rs536304276 is a single position in the genome, in or near the near ECM1P2 gene. Published research associates it with acute laryngitis and tracheitis (phecode 465.4). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs536304276 linked to?

On MyGeneLog this position is linked to Acute Laryngitis and Tracheitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs536304276 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs536304276 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Acute laryngitis and tracheitis (PheCode 465.4) (rs536304276). MyGeneLog™. https://www.mygenelog.com/variants/rs536304276

← See all variants