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Colon polyps

CHRDL2 · rs535025308

Where this position leads

Condition: Colon Polyp

rs535025308 Condition: Colon Polyp Colon Polyp Condition rs535025308 rs535025308 CHRDL2

What the study found

Who was studied 73,737 European ancestry cases, 241,931 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.15 higher (95% confidence interval 0.11-0.19); p = 6 × 10−16.

How common The G allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 11, band 11q13.4 — in an intron of CHRDL2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Colon polyps — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Colon polyps.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Colon polyps compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs535025308

What is rs535025308?

rs535025308 is a single position in the genome, in or near the CHRDL2 gene. Published research associates it with colon polyps. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs535025308 linked to?

On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs535025308 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs535025308 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colon polyps (rs535025308). MyGeneLog™. https://www.mygenelog.com/variants/rs535025308

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