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Cancer (pleiotropy)

FRMD5 · rs533143

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 122,977 European ancestry breast cancer cases, 55,168 European ancestry colorectal cancer cases, 12,906 European ancestry endometrial cancer cases, 4,112 European ancestry esophageal cancer cases, 12,488 European ancestry glioma cancer cases, 6,034 European ancestry head and neck cancer cases, 29,266 European ancestry lung cancer cases, 12,814 European ancestry melanoma cancer cases, 22,406 European ancestry ovarian cancer cases, 8,638 European ancestry pancreatic cancer cases, 79,166 European ancestry prostate cancer cases, 10,784 European ancestry renal cancer cases, 532,864 European ancestry controls.

The effect The reported allele is T; the catalogue records no effect size ; p = 4 × 10−10.

Where it sits Chromosome 15, band 15q15.3 — in an intron of FRMD5.

What each result means

C/C No copy of the version the research linked to Cancer (pleiotropy). This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Cancer (pleiotropy). That is a smaller link than two copies.
T/T Two copies of the version the research linked to Cancer (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions
Lindström S, Wang L, Feng H, Majumdar A, Huo S, Macdonald J, Harrison T, Turman C, Chen H, Mancuso N, Bammler T, Gallinger S
and 49 more — show all
Gruber SB, Gunter MJ, Le Marchand L, Moreno V, Offit K, De Vivo I, O'Mara TA, Spurdle AB, Tomlinson I, Fitzgerald R, Gharahkhani P, Gockel I, Jankowski J, Macgregor S, Schumacher J, Barnholtz-Sloan J, Bondy ML, Houlston RS, Jenkins RB, Melin B, Wrensch M, Brennan P, Christiani DC, Johansson M, Mckay J, Aldrich MC, Amos CI, Landi MT, Tardon A, Bishop DT, Demenais F, Goldstein AM, Iles MM, Kanetsky PA, Law MH, Amundadottir LT, Stolzenberg-Solomon R, Wolpin BM, Klein A, Petersen G, Risch H, Chanock SJ, Purdue MP, Scelo G, Pharoah P, Kar S, Hung RJ, Pasaniuc B, Kraft P
Breast Cancer Association Consortium (BCAC) · Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And Epidemiology Of Colorectal Cancer Consortium (GECCO) · Endometrial Cancer Association Consortium (ECAC) · International Lung Cancer Consortium (ILCCO) · Ovarian Cancer Association Consortium (OCAC) · Pancreatic Cancer Cohort Consortium (Panscan) · Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium
Journal of the National Cancer Institute · 2023 · PMID 36929942

Questions about rs533143

What is rs533143?

rs533143 is a single position in the genome, in or near the FRMD5 gene. Published research associates it with cancer (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs533143 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs533143 come from?

GWAS Catalog, Journal of the National Cancer Institute 2023, PMID:36929942. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Cancer (pleiotropy) (rs533143). MyGeneLog™. https://www.mygenelog.com/variants/rs533143

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