Sensitive

Rheumatoid arthritis

near HLA-DQA1 · rs532322163

Where this position leads

Condition: Rheumatoid Arthritis

rs532322163 Condition: Rheumatoid Arthritis Rheumatoid Arthritis Condition rs532322163 rs532322163 near HLA-DQA1

What the study found

Who was studied 5,348 East Asian ancestry cases, 173,268 East Asian ancestry controls.

The effect Each copy of the T allele shifted the measure 0.864 higher (95% confidence interval 0.8-0.93); p = 2 × 10−152.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 1.8 kb from HLA-DQA1.

What each result means

A/A No copy of the version the research linked to Rheumatoid arthritis. This is the starting point the study compared everyone against.
A/T One copy of the version the research linked to Rheumatoid arthritis. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Rheumatoid arthritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs532322163

What is rs532322163?

rs532322163 is a single position in the genome, in or near the near HLA-DQA1 gene. Published research associates it with rheumatoid arthritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs532322163 linked to?

On MyGeneLog this position is linked to Rheumatoid Arthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs532322163 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs532322163 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Rheumatoid arthritis (rs532322163). MyGeneLog™. https://www.mygenelog.com/variants/rs532322163

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