Gene Knowledge Graph
UTC
Sensitive

Takes medication for celiac disease/sprue?

near DDX59-AS1 · rs530510527

Where this position leads

Condition: Celiac Disease

rs530510527 Condition: Celiac Disease Celiac Disease Condition rs530510527 rs530510527 near DDX59-A…

What the study found

Who was studied 243 African American or Afro-Caribbean cases, 55,262 African American or Afro-Caribbean controls, 832 European ancestry cases, 314,836 European ancestry controls.

The effect Each copy of the C allele shifted the measure 2.33 lower (95% confidence interval 2.28-2.37); p = 2 × 10−12.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 1, band 1q32.1 — between genes, 5 kb from DDX59-AS1.

What each result means

C/C Two copies of the version the research linked to Takes medication for celiac disease/sprue?. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Takes medication for celiac disease/sprue?. That is a smaller link than two copies.
T/T No copy of the version the research linked to Takes medication for celiac disease/sprue?. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs530510527

What is rs530510527?

rs530510527 is a single position in the genome, in or near the near DDX59-AS1 gene. Published research associates it with takes medication for celiac disease/sprue?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs530510527 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs530510527 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs530510527 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Takes medication for celiac disease/sprue? (rs530510527). MyGeneLog™. https://www.mygenelog.com/variants/rs530510527

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