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Takes medication for ulcerative colitis?

near NDUFB5P1 · rs529914570

Where this position leads

Condition: Ulcerative Colitis

rs529914570 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs529914570 rs529914570 near NDUFB5P1

What the study found

Who was studied 491 African American or Afro-Caribbean cases, 55,014 African American or Afro-Caribbean controls, 2,625 European ancestry cases, 313,043 European ancestry controls, 242 Hispanic or Latin American cases, 29,072 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 2.56 lower (95% confidence interval 2.51-2.6); p = 4 × 10−11.

How common The C allele had a frequency of about 100% in the people studied.

Where it sits Chromosome 4, band 4q34.3 — between genes, 59.3 kb from NDUFB5P1.

What each result means

A/A No copy of the version the research linked to Takes medication for ulcerative colitis?. This is the starting point the study compared everyone against.
A/C One copy of the version the research linked to Takes medication for ulcerative colitis?. That is a smaller link than two copies.
C/C Two copies of the version the research linked to Takes medication for ulcerative colitis?. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs529914570

What is rs529914570?

rs529914570 is a single position in the genome, in or near the near NDUFB5P1 gene. Published research associates it with takes medication for ulcerative colitis?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs529914570 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

Does having rs529914570 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs529914570 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for ulcerative colitis? (rs529914570). MyGeneLog™. https://www.mygenelog.com/variants/rs529914570

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