Standard
Estimated bone mineral density
FMNL3 · rs529326509
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 448,010 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.32 higher (95% confidence interval 0.27-0.37); p = 6 × 10−39.
Where it sits Chromosome 12, band 12q13.12 — in an intron of FMNL3.
What each result means
A/A
Published research associates this genotype with typical/baseline likelihood of Estimated bone mineral density — no copies of the reported risk allele.
A/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Estimated bone mineral density.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Estimated bone mineral density compared to the general population.
Source
Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
Chai RC,
Lundberg M,
Freudenthal B,
Smith JT,
Boughton AP,
Zhang Y,
Flynn KA,
Frysz M,
Corr AP,
Khoo WH,
Komla-Ebri D,
Dack MRG
and 38 more — show all
Guilfoyle SE,
Logan JG,
Butterfield NC,
Leitch VD,
Pollard AS,
Mäkitie RE,
Bradford N,
Ramos-Mucci L,
Vilas-Zornoza A,
Chen Y,
Yip RKH,
Er J,
Tan SZ,
McDonald MM,
Youlten SE,
Sergio CM,
Castro-Martinez A,
Young SG,
Skorokhodova E,
Evans DM,
Powell JE,
de Leeuw CA,
Ewing AD,
Eisman JA,
Blank RD,
Phan TG,
Lagendijk AK,
Hawkins ED,
Oh HL,
McIntyre RE,
Hessel EM,
Taylor-King JP,
Baldock PA,
Duncan EL,
Williams GR,
Bassett JHD,
Croucher PI,
Kemp JP
Nature genetics · 2026 · PMID 42432248 · open access
Questions about rs529326509
What is rs529326509?
rs529326509 is a single position in the genome, in or near the FMNL3 gene. Published research associates it with estimated bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs529326509 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs529326509 come from?
GWAS Catalog, Nature genetics 2026, PMID:42432248. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Estimated bone mineral density (rs529326509). MyGeneLog™. https://www.mygenelog.com/variants/rs529326509
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