Standard
Mosaic loss of chromosome Y (Y chromosome dosage)
TMEM54 · rs527504
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Mosaic loss of chromosome Y (Y chromosome dosage) compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Mosaic loss of chromosome Y (Y chromosome dosage).
G/G
Published research associates this genotype with typical/baseline likelihood of Mosaic loss of chromosome Y (Y chromosome dosage) — no copies of the reported risk allele.
Source
GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
Terao C,
Momozawa Y,
Ishigaki K,
Kawakami E,
Akiyama M,
Loh PR,
Genovese G,
Sugishita H,
Ohta T,
Hirata M,
Perry JRB,
Matsuda K
and 3 more — show all
Nature communications · 2019 · PMID 31624269 · open access
Questions about rs527504
What is rs527504?
rs527504 is a single position in the genome, in or near the TMEM54 gene. Published research associates it with mosaic loss of chromosome y (y chromosome dosage). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs527504 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs527504 come from?
GWAS Catalog, Nat Commun 2019, PMID:31624269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants