3 432217123223Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,764 European ancestry cases, 10,475 European ancestry controls; replicated in 3,716 European ancestry cases, 4,261 European ancestry controls.
The effect
Each copy of the C allele carried 1.15 times the odds of Primary biliary cholangitis (95% confidence interval 1.08-1.23); p = 1 × 10−8.
Where it sits Chromosome 5, band 5q21.1 — between genes, 67 kb from MACIR.
What each result means
C/CTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
Nature communications · 2015 · PMID 26394269 · open access
Questions about rs526231
What is rs526231?
rs526231 is a single position in the genome, in or near the PAM gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs526231 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs526231 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs526231 come from?
GWAS Catalog, Nat Commun 2015, PMID:26394269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 432217123223Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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