Standard
Primary biliary cholangitis
PAM · rs526231
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
C/C
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Primary biliary cholangitis compared to the general population.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Primary biliary cholangitis.
T/T
Published research associates this genotype with typical/baseline likelihood of Primary biliary cholangitis — no copies of the reported risk allele.
Source
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Cordell HJ,
Han Y,
Mells GF,
Li Y,
Hirschfield GM,
Greene CS,
Xie G,
Juran BD,
Zhu D,
Qian DC,
Floyd JA,
Morley KI
and 11 more — show all
Prati D,
Lleo A,
Cusi D,
Gershwin ME,
Anderson CA,
Lazaridis KN,
Invernizzi P,
Seldin MF,
Sandford RN,
Amos CI,
Siminovitch KA
Nature communications · 2015 · PMID 26394269 · open access
Questions about rs526231
What is rs526231?
rs526231 is a single position in the genome, in or near the PAM gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs526231 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs526231 come from?
GWAS Catalog, Nat Commun 2015, PMID:26394269. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants