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Sensitive

Systemic sclerosis

TNFAIP3 · rs5029949

Where this position leads

Condition: Systemic Sclerosis

rs5029949 Condition: Systemic Sclerosis Systemic Sclerosis Condition rs5029949 rs5029949 TNFAIP3

What the study found

Who was studied 1,428 Japanese ancestry cases, 112,599 Japanese ancestry controls.

The effect Each copy of the G allele shifted the measure 0.175 higher (95% confidence interval 0.052-0.298); p = 2 × 10−10.

How common The G allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 6, band 6q23.3 — in an intron of TNFAIP3.

What each result means

A/A No copy of the version the research linked to Systemic sclerosis. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Systemic sclerosis. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Systemic sclerosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
GWAS for systemic sclerosis identifies six novel susceptibility loci including one in the Fcγ receptor region
Ishikawa Y, Tanaka N, Asano Y, Kodera M, Shirai Y, Akahoshi M, Hasegawa M, Matsushita T, Saito K, Motegi SI, Yoshifuji H, Yoshizaki A
and 60 more — show all
Kohmoto T, Takagi K, Oka A, Kanda M, Tanaka Y, Ito Y, Nakano K, Kasamatsu H, Utsunomiya A, Sekiguchi A, Niiro H, Jinnin M, Makino K, Makino T, Ihn H, Yamamoto M, Suzuki C, Takahashi H, Nishida E, Morita A, Yamamoto T, Fujimoto M, Kondo Y, Goto D, Sumida T, Ayuzawa N, Yanagida H, Horita T, Atsumi T, Endo H, Shima Y, Kumanogoh A, Hirata J, Otomo N, Suetsugu H, Koike Y, Tomizuka K, Yoshino S, Liu X, Ito S, Hikino K, Suzuki A, Momozawa Y, Ikegawa S, Tanaka Y, Ishikawa O, Takehara K, Torii T, Sato S, Okada Y, Mimori T, Matsuda F, Matsuda K, Amariuta T, Imoto I, Matsuo K, Kuwana M, Kawaguchi Y, Ohmura K, Terao C
Nature communications · 2024 · PMID 38296975 · open access

Questions about rs5029949

What is rs5029949?

rs5029949 is a single position in the genome, in or near the TNFAIP3 gene. Published research associates it with systemic sclerosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs5029949 linked to?

On MyGeneLog this position is linked to Systemic Sclerosis. The research behind each link, and its sources, are set out on that condition page.

Does having rs5029949 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5029949 come from?

GWAS Catalog, Nature communications 2024, PMID:38296975. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic sclerosis (rs5029949). MyGeneLog™. https://www.mygenelog.com/variants/rs5029949

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