Standard

Hemoglobin concentration

near PLEKHM1 · rs5026246

Where this position leads

Condition: Blood Cell Counts

rs5026246 Condition: Blood Cell Counts Blood Cell Counts Condition rs5026246 rs5026246 near PLEKHM1

What the study found

Who was studied 46,904 European ancestry males; replicated in 80,822 European ancestry males.

The effect Each copy of the G allele shifted the measure 0.0525 higher; p = 6 × 10−32.

How common The G allele had a frequency of about 23% in the people studied.

Where it sits Chromosome 17, band 17q21.31 — between genes, 4.8 kb from PLEKHM1.

What each result means

G/G Two copies of the version the research linked to Hemoglobin concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Hemoglobin concentration. That is a smaller link than two copies.
T/T No copy of the version the research linked to Hemoglobin concentration. This is the starting point the study compared everyone against.
Source

Questions about rs5026246

What is rs5026246?

rs5026246 is a single position in the genome, in or near the near PLEKHM1 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs5026246 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs5026246 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5026246 come from?

GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hemoglobin concentration (rs5026246). MyGeneLog™. https://www.mygenelog.com/variants/rs5026246

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