Standard

Glomerular filtration rate

SHROOM3 · rs5020545

Where this position leads

Condition: Kidney Function

rs5020545 Condition: Kidney Function Kidney Function Condition rs5020545 rs5020545 SHROOM3

What the study found

Who was studied 23,553 European ancestry individuals, 23,536 Japanese individuals, 16,325 Hispanic individuals, 8,224 African American individuals.

The effect Each copy of the T allele shifted the measure 1.12 lower (95% confidence interval 0.8-1.43); p = 6 × 10−12.

How common The T allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 4, band 4q21.1 — in an intron of SHROOM3.

What each result means

C/C No copy of the version the research linked to Glomerular filtration rate. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Glomerular filtration rate. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Glomerular filtration rate. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs5020545

What is rs5020545?

rs5020545 is a single position in the genome, in or near the SHROOM3 gene. Published research associates it with glomerular filtration rate. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs5020545 linked to?

On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.

Does having rs5020545 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs5020545 come from?

GWAS Catalog, Am J Hum Genet 2016, PMID:27588450. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glomerular filtration rate (rs5020545). MyGeneLog™. https://www.mygenelog.com/variants/rs5020545

← See all variants