Standard

high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed)

near PPARG · rs4998049

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

Strength of the evidence

2 / 4

Its strongest genetic-study result is p = 10⁻⁴⁶, with 5 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 404,121 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0442 higher (95% confidence interval 0.038-0.05); p = 8 × 10⁻⁴⁷.

How common The A allele had a frequency of about 59% in the people studied.

Where it sits Chromosome 3, band 3p25.2 — between genes, 11.1 kb from PPARG.

How common each version is

AG

Korean Korea4K

A 99.9% · G 0.1%

Japanese ToMMo

A 99.9% · G 0.1%

World gnomAD

A 100.0% · G 0.0%

World 1000 Genomes

A 68.6% · G 31.4%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

A/A Two copies of the version the research linked to high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed). That is a smaller link than two copies.

G/G No copy of the version the research linked to high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed). This is the starting point the study compared everyone against.

Source

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program

Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F

and 59 more — show all

Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs4998049

What is rs4998049?

rs4998049 is a single position in the genome, in or near the near PPARG gene. Published research associates it with high density lipoprotein cholesterol (hdlc, mean, inv-norm transformed). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4998049 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4998049 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) (rs4998049). MyGeneLog™. https://www.mygenelog.com/variants/rs4998049

← See all variants